ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,491,249, issued on Dec. 9, was assigned to Rakuten Medical Inc. (San Diego).

"Methods for manufacturing phthalocyanine dye conjugates and stable conjugates" was invented by Lewis R. Makings (Encinitas, Calif.), Roger Heim (Del Mar, Calif.) and Miguel Garcia-Guzman (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are methods for manufacturing a conjugate containing a phthalocyanine dye, including methods that include one or more steps of preparing or producing the conjugate, formulating the conjugate and packaging the conjugate. In some aspects, the manufacturing methods result in the generation of a stable conjugate. Also provided are s...