ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,460,252, issued on Nov. 4, was assigned to Quest Diagnostics Investments LLC (Secaucus, N.J.).
"MLH1 methylation assay" was invented by Amber C. Donahue (San Juan Capistrano, Calif.) and Feras Hantash (San Juan Capistrano, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present technology relates to methods for excluding Lynch syndrome as a possible diagnosis in patients suffering from colorectal cancers or endometrial cancers. These methods are based on detecting the methylation status of the MLH1 promoter 'C' region in colorectal and endometrial cancer patients using an improved and highly sensitive methylation-specific multiplex ligation-dep...