ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,595, issued on March 18, was assigned to QINGDAO UNIVERSITY (Qingdao, China).

"Preparation method of 4D chitosan-based thermosensitive hydrogel" was invented by Wenhua Xu (Shandong, China), Yanhan Dong (Shandong, China), Lixia Zhang (Shandong, China) and Yuqiao Fan (Shandong, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "Medical material production and preparation, and a preparation method of a 4D chitosan-based thermosensitive hydrogel. First, chitosan is dissolved in acetic acid solution; a chitosan-based thermosensitive hydrogel is printed by a 4D bioprinter and lyophilized after solvent extraction, to obtain lyophilized chitosan; subsequ...