ALEXANDRIA, Va., July 23 -- United States Patent no. 12,366,508, issued on July 22, was assigned to QIAGEN GmbH (Hilden, Germany).
"Method of preparing a frozen biological sample" was invented by Daniel Grolz (Hilden, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention pertains to a method of preparing a frozen biological sample, comprising the steps of fixing the biological sample with a non-crosslinking fixative solution, incubating the fixed biological sample in an aqueous solution comprising a cryoprotectant, and freezing the cryoprotected biological sample. The method advantageously allows to preserve both, morphology of the sample as well as biological components such as nuclei...