US Patent Issued to Promega on Oct. 7 for "Oplophorus -derived luciferases, novel coelenterazine substrates, and methods of use" (Wisconsin Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,354, issued on Oct. 7, was assigned to Promega Corp. (Madison, Wis.).

"Oplophorus -derived luciferases, novel coelenterazine substrates, and methods of use" was invented by Brock Binkowski (Sauk City, Wis.), Lance P. Encell (Fitchburg, Wis.), Mary Hall (Waunakee, Wis.), Matthew B. Robers (Madison, Wis.), Michael R. Slater (Madison, Wis.), Keith V. Wood (Mount Horeb, Wis.) and Monika G. Wood (Mount Horeb, Wis.).

According to the abstract* released by the U.S. Patent & Trademark Office: "An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one ami...