ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,460,250, issued on Nov. 4, was assigned to President and Fellows of Harvard College (Cambridge, Mass.).

"Amplification methods and systems for MERFISH and other applications" was invented by Xiaowei Zhuang (Cambridge, Mass.), Chenglong Xia (Cambridge, Mass.) and Jeffrey R. Moffitt (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention generally relates to systems and methods for imaging or determining nucleic acids in cells or other samples. In some cases, the transcriptome of a cell may be determined. Certain embodiments are generally directed to determining nucleic acids and other targets in a sample at relatively high r...