US Patent Issued to PRESIDENT AND FELLOWS OF HARVARD COLLEGE on March 25 for "Stapled and stitched polypeptides and uses thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,423, issued on March 25, was assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Mass.).

"Stapled and stitched polypeptides and uses thereof" was invented by Gregory L. Verdine (Boston) and Gerard Hilinski (Somerville, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides stapled polypeptides of the Formulae (I) and (VI):and salts thereof; wherein the groups; R1a, R1b, R1c, R2a, R3a, R2b, R3b, R4a, R4b, RA, RZ, L1a, L1b, L2, L3, XAA, v, w, p, m, s, n, t, and q are as defined herein. The present invention further provides methods of preparing the inventive stapled polypeptides from unstapled polypeptide pre...