US Patent Issued to President and Fellows of Harvard College on Feb. 4 for "Cas variants for gene editing" (Massachusetts Inventors)

ALEXANDRIA, Va., Feb. 5 -- United States Patent no. 12,215,365, issued on Feb. 4, was assigned to President and Fellows of Harvard College (Cambridge, Mass.).

"Cas variants for gene editing" was invented by David R. Liu (Cambridge, Mass.) and Alexis Christine Komor (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided....