ALEXANDRIA, Va., July 9 -- United States Patent no. 12,351,839, issued on July 8, was assigned to Precision BioSciences Inc. (Durham, N.C.).
"Rationally-designed single-chain meganucleases with non-palindromic recognition sequences" was invented by James Jefferson Smith (Morrisville, N.C.) and Derek Jantz (Durham, N.C.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non-palindromic recognition sequence. The invention also relates to methods of producing such megan...