ALEXANDRIA, Va., July 3 -- United States Patent no. 12,344,645, issued on July 1, was assigned to POLARIS GROUP (Grand Cayman, Cayman Islands).
"Protein conjugates" was invented by Robert J. Almassy (Vista, Calif.), Elena Brin (San Diego), Richard E. Showalter (El Cajon, Calif.) and James A. Thomson (San Diego).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are conjugates of an arginine deiminase (ADI) and a Tumor Necrosis Factor (TNF) superfamily ligand, and related compositions and methods of use thereof. Also provided are conjugates of a hexameric polypeptide and a trimeric polypeptide, conjugates of a first and second trimeric polypeptide, and related compositions and methods of use thereof."
Th...