US Patent Issued to PMV PHARMACEUTICALS on Sept. 23 for "Companion diagnostic tool for mutant p53 reactivating compounds" (New Jersey Inventor)

ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,419,880, issued on Sept. 23, was assigned to PMV PHARMACEUTICALS INC. (Princeton, N.J.).

"Companion diagnostic tool for mutant p53 reactivating compounds" was invented by Melissa Dumble (Watchung, N.J.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compound...