ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,416,040, issued on Sept. 16, was assigned to PIXELGEN TECHNOLOGIES AB (Stockholm).
"Spatial mapping by serial primer extension" was invented by Simon Fredriksson (Bromma, Sweden) and Filip Karlsson (Solna, Sweden).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein is probe system comprising: a population of nucleic acid molecules that have an extendible end, a first set of barcoded particles that each have a nucleotide sequence comprising: (i) a binding sequence that is complementary to the extendible end of the nucleic acid molecules, (ii) a unique particle identifier sequence, and (iii) a first template sequence, and a second set of barcod...