US Patent Issued to Personal Genome Diagnostics on Dec. 16 for "Method of improving prediction of response for cancer patients treated with immunotherapy" (Maryland Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,661, issued on Dec. 16, was assigned to Personal Genome Diagnostics Inc. (Baltimore).

"Method of improving prediction of response for cancer patients treated with immunotherapy" was invented by Nicholas C. Dracopoli (Baltimore) and Gustavo Cerqueira (Baltimore).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method of determining a therapeutic regimen in a patient with cancer comprising determining in a sample from the patient the tumor mutation burden (TMB) and loss of heterozygosity (LOH), wherein high TMB in combination with no LOH is indicative of a positive outcome when treated with a checkpoint inhibitor and high TMB with LOH is indicative of ...