US Patent Issued to PAQ Therapeutics on Sept. 2 for "KRAS G12D proteolysis targeting chimeras" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 3 -- United States Patent no. 12,404,285, issued on Sept. 2, was assigned to PAQ Therapeutics Inc. (Burlington, Mass.).

"KRAS G12D proteolysis targeting chimeras" was invented by Nan Ji (Arlington, Mass.), Ning Yin (Lexington, Mass.) and Hui Qiu (Acton, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are KRAS G12D proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS G12D PROTACs, and methods of making and using the KRAS G12D PROTACs, e.g., to promote degradation of KRAS G12D and/or treat KRAS G12D-associated cancers. In an embodiment, the KRAS G12D PROTAC has the following structural formula:[KRAS G12Di]-L'-[Degron],or a pharmaceutically accep...