ALEXANDRIA, Va., Dec. 31 -- United States Patent no. 12,509,517, issued on Dec. 30, was assigned to OXFORD UNIVERSITY INNOVATION Ltd. (Oxford, Great Britain).
"Modified antibodies" was invented by Simon John Davis (Oxford, Great Britain).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are antibody construct molecules comprising (i) an Fc receptor binding site, (ii) an antigen-binding site and (iii) a spacer moiety located between (i) and (ii), wherein the spacer moiety serves to increase the distance between (i) and (ii) so as to reduce the agonistic activity of the molecule as compared to the antibody variant that lacks (iii). Disclosed are various antibodies that can be de-agonized by introdu...