ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,414, issued on March 25, was assigned to Ossianix Inc. (Philadelphia).
"Anti-CD98hc VNARs for crossing the blood brain barrier and type IV VNAR libraries" was invented by Krzysztof Bartlomiej Wicher (Cambridge, Great Britain), Jaroslaw Michal Szary (Cambridge, Great Britain), Julia Lynn Rutkowski (Bryn Mawr, Pa.), Fabrizio Comper (Knebworth, Great Britain) and Pawel Stocki (Royston, Great Britain).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to CD98hc binding moieties with high specificity and with ability to cross the blood brain barrier (BBB). Such moieties may be used alone or as components in specific conjugates t...