ALEXANDRIA, Va., July 3 -- United States Patent no. 12,343,446, issued on July 1, was assigned to OSIRIS THERAPEUTICS INC..

"Bone repair product and methods of use thereof" was invented by Thomas E. Uveges (Elkridge, Md.), Jin-Qiang Kuang (Glenelg, Md.), Alla Danilkovitch (Columbia, Md.), S. Michael Sinclair (Ellicott City, Md.) and Sandra D. Geraghty (Elkridge, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use ...