ALEXANDRIA, Va., July 30 -- United States Patent no. 12,371,502, issued on July 29, was assigned to OSE IMMUNOTHERAPEUTICS (Nantes, France).
"Antibodies directed against CD127" was invented by Nicolas Poirier (Treillieres, France), Caroline Mary (Sainte-Pazanne, France) and Bernard Vanhove (Reze, France).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to antibodies directed against CD127, the alpha chain of the interleukin 7 (IL-7) receptor IL-7R), and which have antagonist properties for IL-7-IL-7R interaction, may present cytotoxic activity against CD127 positive cells but do not increase the maturation of dendritic cells (DCs) induced by TSLP, a cytokine also using CD127 as part of its...