ALEXANDRIA, Va., June 16 -- United States Patent no. 12,305,192, issued on May 20, was assigned to OSAKA UNIVERSITY (Osaka, Japan).

"Method for producing artificial recombinant RNA virus stably retaining foreign gene" was invented by Takeshi Kobayashi (Osaka, Japan) and Yuta Kanai (Osaka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a method for producing an artificial recombinant RNA virus stably expressing a foreign gene, comprising the steps of: (1) obtaining a foreign gene having a modified codon composition similar to that of an RNA virus gene; (2) inserting the foreign gene obtained in step (1) into an RNA virus genome; and (3) artificially synthesizing an artificial recombinant RNA...