ALEXANDRIA, Va., July 23 -- United States Patent no. 12,365,923, issued on July 22, was assigned to OSAKA UNIVERSITY (Suita, Japan).
"Method for producing genome-edited cell" was invented by Shinichiro Nakada (Suita, Japan) and Akiko Tomita (Suita, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "Nicks were generated at multiple sites in the neighboring DNA region of the nucleotide to be modified on the recipient chromosome, and on the donor chromosome, a nick was generated at at least one site corresponding to the site where a nick was to be generated on the recipient chromosome. Thereby, the present inventors have succeeded in significantly suppressing non-homologous end joining and specifically induci...