ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,546,776, issued on Feb. 10, was assigned to Orionis Biosciences Inc. (Waltham, Mass.).
"Modulation of protein degradation" was invented by Nikolai Kley (Waltham, Mass.), Samuel Lievens (Ghent, Belgium) and Riccardo Sabatini (Waltham, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Methods of assessing the efficacy of an agent in treating a disease or disorder are provided that include determining whether the agent causes, or inhibits, direct or indirect recruitment and/or ubiquitination and/or degradation of argininosuccinate synthetase 1 (ASS1)."
The patent was filed on Dec. 15, 2020, under Application No. 17/785,181.
*For further information, i...