ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,377, issued on Dec. 16, was assigned to ONO PHARMACEUTICAL Co. LTD. (Osaka, Japan).
"Tricyclic spiro compound" was invented by Masaki Asada (Osaka, Japan), Kousuke Tani (Osaka, Japan), Masaya Hirobe (Osaka, Japan), Satonori Higuchi (Osaka, Japan), Kazuhiro Fuchibe (Osaka, Japan), Ryo Oikawa (Osaka, Japan), Tohru Kotani (Osaka, Japan) and Hirotsugu Takano (Osaka, Japan).
According to the abstract* released by the U.S. Patent & Trademark Office: "A medicinal agent for the prevention and/or treatment of diseases caused by EP4 receptor activation is disclosed. A compound having antagonistic activity against the EP4 receptor is contained as an active ingredient in the medicinal agent....