US Patent Issued to Ohio State Innovation Foundation on Sept. 16 for "Nucleobase editors and methods of use thereof" (Ohio, Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,416,001, issued on Sept. 16, was assigned to Ohio State Innovation Foundation (Columbus, Ohio).

"Nucleobase editors and methods of use thereof" was invented by Renzhi Han (Columbus, Ohio), Li Xu (Bedford, Mass.) and Yandi Gao (Powell, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to nucleobase editors and methods of use thereof. Disclosed herein are fusion proteins, systems, and compositions for editing disease-associated mutations and methods of use thereof. In some aspects, disclosed herein is a fusion protein comprising a Cas9 nickase and a nucleotide deaminase, wherein the Cas9 nickase comprises a first amino ac...