ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,181, issued on April 22, was assigned to Ohio State Innovation Foundation (Columbus, Ohio).
"Bicyclic peptidyl inhibitors" was invented by Dehua Pei (Columbus, Ohio).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides a large combinatorial library of cell-permeable bicyclic peptides. The bicyclic peptides described herein include the first ring consisted of randomized peptide sequences for potential binding to a target of interest while the second ring featured a family of different cell-penetrating motifs, for both cell penetration and target binding. The library was screened against the IKappaB kinase Alpha/Beta (IKKAlpha/...