ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,522,654, issued on Jan. 13, was assigned to Novartis AG (Basel, Switzerland).
"Engineered heterodimeric proteins" was invented by Regis Cebe (Saint-Louis, France), Sebastien Irigaray (Mulhouse, France) and Darko Skegro (Grenchen, Switzerland).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides heterodimeric antibodies and fragments thereof and methods for their preparation, wherein the pairing of heavy and light chains has been improved. Interface residues were mutated such that each light chain strongly favoured its cognate heavy chain when two different heavy chains and two different light chains were co-transfected and co-exp...