US Patent Issued to Northwestern University on May 27 for "Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein" (Illinois Inventors)

ALEXANDRIA, Va., June 17 -- United States Patent no. 12,311,029, issued on May 27, was assigned to Northwestern University (Evanston, Ill.).

"Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein" was invented by Gary E. Schiltz (Naperville, Ill.) and Derek A. Wainwright (Brookfield, Ill.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of IDO protein. The disclosed PROTACs typically include a first targeting moiety that binds to IDO (Miro). The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to a...