US Patent Issued to Northwestern University on Dec. 9 for "Substituted [1,2,4triazolo[4,3-cpyrimidines that induce degradation of embryonic ectoderm development (EED) protein" (Illinois Inventors)

ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,492,209, issued on Dec. 9, was assigned to Northwestern University (Evanston, Ill.).

"Substituted [1,2,4triazolo[4,3-cpyrimidines that induce degradation of embryonic ectoderm development (EED) protein" was invented by Gary E. Schiltz (Naperville, Ill.) and Jindan Yu (Evanston, Ill.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are compounds that bind to embryonic ectoderm development (EED) protein and proteolysis-targeting chimeric (PROTAC) derivatives thereof that induce degradation of EED. The disclosed compounds may be characterized as substituted [1,2,4]triazolo[4,3-c]pyrimidin-5-amine compounds having the Formula I:where R1 is as disclos...