US Patent Issued to NORTHWESTERN UNIVERSITY on Aug. 5 for "Sequence multiplicity within spherical nucleic acids" (Illinois Inventors)

ALEXANDRIA, Va., Aug. 6 -- United States Patent no. 12,378,560, issued on Aug. 5, was assigned to NORTHWESTERN UNIVERSITY (Evanston, Ill.).

"Sequence multiplicity within spherical nucleic acids" was invented by Chad A. Mirkin (Wilmette, Ill.) and Ziyin Huang (Evanston, Ill.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure is directed to spherical nucleic acids (SNAs) comprising a nanoparticle core and an oligonucleotide shell attached to the external surface of the nanoparticle core, wherein the oligonucleotide shell comprises a mixture of class A CpG oligonucleotides and class B CpG oligonucleotides. The disclosure also provides methods of using the SNAs for, e.g., regulation of an immu...