ALEXANDRIA, Va., Sept. 3 -- United States Patent no. 12,404,367, issued on Sept. 2, was assigned to NOF Corp. (Tokyo) and TOKYO INSTITUTE OF TECHNOLOGY (Tokyo).
"Degradable multi-arm polyethylene glycol derivative" was invented by Hiroki Yoshioka (Kawasaki, Japan), Ken Hamura (Kawasaki, Japan), Kazuki Osakama (Kawasaki, Japan) and Nobuhiro Nishiyama (Tokyo).
According to the abstract* released by the U.S. Patent & Trademark Office: "A multi-arm, degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A degradable polyethylene glycol derivative represented by the following formula (1):wherein n1 and n2 are each independently 45-950, W1 and W2 are each independently an oli...