ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,459,925, issued on Nov. 4, was assigned to NodThera Ltd. (Little Chesterford, Great Britain).
"Sulphonyl urea derivatives as NLRP3 inflammasome modulators" was invented by David Harrison (Essex, Great Britain), Alan Paul Watt (Edinburgh, Great Britain) and Mark G. Bock (Lexington, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to compounds of Formula (I):and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may ...