ALEXANDRIA, Va., June 9 -- United States Patent no. 12,286,478, issued on April 29, was assigned to NextCure Inc. (Beltsville, Md.).
"B7-H4 antibodies and methods of use thereof" was invented by Solomon Langermann (Baltimore), Dallas Benjamin Flies (Rockville, Md.) and Linda Liu (Clarksville, Md.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Compositions and methods of use thereof for modulating B7-H4 are provided. For example, immunomodulatory agents are provided that reduce B7-H4 expression, ligand binding, crosslinking, negative signaling, or a combination thereof. Such agents can be used to increase an immune response in a subject in need thereof. Immunomodulatory agents are also provided that increase ...