ALEXANDRIA, Va., June 16 -- United States Patent no. 12,305,188, issued on May 20, was assigned to NEURACLE GENETICS INC. (Seoul, South Korea).
"Dual helper plasmid" was invented by Joo Seok Han (Seoul, South Korea), Hoon Young Kong (Seoul, South Korea) and Yoon Hyung Hwang (Seoul, South Korea).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to a dual helper plasmid for producing a recombinant adeno-associated virus. A double transfection method using the dual helper plasmid of the present disclosure is advantageous over the triple transfection method typically used for production of adeno-associated virus in terms of 1) increased chance of co-transfection, 2) increased productiv...