US Patent Issued to NELSON MANDELA UNIVERSITY on Nov. 4 for "Continuous flow synthesis method for the manufacture of isoniazid" (South African Inventors)

ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,459,897, issued on Nov. 4, was assigned to NELSON MANDELA UNIVERSITY (Port Elizabeth, South Africa).

"Continuous flow synthesis method for the manufacture of isoniazid" was invented by Paul Watts (Port Elizabeth, South Africa) and Ruvimbo Mangwiro (Randfontein, South Africa).

According to the abstract* released by the U.S. Patent & Trademark Office: "A multistep continuous flow synthesis method for the manufacture of isonicotinyl-hydrazide (Isoniazid) comprising reacting 4-cyano pyridine with NaOH at a specified molar ratio and temperature range to produce the intermediate isonicotinamide, which intermediate is reacted with hydrazine hydrate, without isolation thereof, at a specified ...