ALEXANDRIA, Va., July 3 -- United States Patent no. 12,344,888, issued on July 1, was assigned to NCAN GENOMICS INC. (Vancouver, Canada).
"Linked ligation" was invented by Andrea Marziali (North Vancouver, Canada) and Joel Pel (Vancouver, Canada).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention generally relates to capturing, amplifying, and sequencing nucleic acids. In certain embodiments, copies of the sense and antisense strands of a duplex template nucleic acid are captured using linked capture probes and multiple binding and extension steps to improve specificity over traditional single binding target capture techniques. Methods of seeding sequencing clusters with sense and antisense strands ...