US Patent Issued to NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY on Oct. 14 for "Microglial selective gene expression vector" (Japanese Inventors)

ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,442,017, issued on Oct. 14, was assigned to NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY (Gunma, Japan).

"Microglial selective gene expression vector" was invented by Hirokazu Hirai (Gunma, Japan) and Yukihiro Okada (Gunma, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "A promoter on an AAV vector was changed to an Iba1 promoter, and a configuration that combined a miR-9 complementary sequence (miR-9T) and a miR-129 complementary sequence (miR-129T) was adopted. An exogenous gene was clarified to be efficiently and specifically expressed in microglia by using this vector, resulting in that an AAV vector that could efficiently and specifically ...