US Patent Issued to National Research Council of Canada on Feb. 3 for "Anti-EGFRvIII antibodies and antigen-binding fragments thereof" (Canadian Inventors)

ALEXANDRIA, Va., Feb. 3 -- United States Patent no. 12,540,186, issued on Feb. 3, was assigned to National Research Council of Canada (Ottawa).

"Anti-EGFRvIII antibodies and antigen-binding fragments thereof" was invented by Anne Marcil (Pierrefonds, Canada), Maria Jaramillo (Beaconsfield, Canada), Traian Sulea (Kirkland, Canada), Maria Moreno (Ottawa) and Cunle Wu (Montreal).

According to the abstract* released by the U.S. Patent & Trademark Office: "Antigen-binding agents such as antibodies or antigen-binding fragments thereof, chimeric antigen receptors (CARs), bispecific T-cell engagers (BiTEs) and the like that specifically bind to epidermal growth factor receptor variant III (EGFRvIII) are provided. The EGFRvIII-specific antibodies ...