US Patent Issued to NantBio on March 18 for "Chimeric T cell receptors, nucleic acids, and methods of making and using the same" (California Inventor)

ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,525, issued on March 18, was assigned to NantBio Inc. (Culver City, Calif.).

"Chimeric T cell receptors, nucleic acids, and methods of making and using the same" was invented by Hermes Garban (Los Angeles).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compositions and methods for eradicating tumor cells using novel compositions are contemplated. In one aspect, a pharmaceutical composition comprising a CAR scaffold and an antigen binding domain in a single chimeric species is provided. In some aspects, the CAR scaffold may comprise a CD28 costimulatory signaling region and a CD3Zeta activation domain or a complete CD3Zeta activation domain. In some ...