US Patent Issued to Monsanto Technology on July 29 for "Methods and compositions to promote targeted genome modifications using HUH endonucleases" (Missouri Inventor)

ALEXANDRIA, Va., July 30 -- United States Patent no. 12,371,695, issued on July 29, was assigned to Monsanto Technology LLC (St. Louis).

"Methods and compositions to promote targeted genome modifications using HUH endonucleases" was invented by Ervin D. Nagy (St. Louis).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure provides compositions and methods for improving site-directed integration of nucleic acids using RNA-guided nucleases coupled with HUH endonucleases. In one aspect, this disclosure provides a ribonucleoprotein comprising: (a) a re-combinant polypeptid comprising: (i) an amino acid sequence encoding a Cas12a nuclease; (ii) an amino acid sequence encoding a linker; and (iii) an amino...