US Patent Issued to Miltenyi Biotec on April 29 for "Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains" (German Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,286,465, issued on April 29, was assigned to Miltenyi Biotec B.V. & Co. KG (Bergisch Gladbach, Germany).

"Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains" was invented by Rita Pfeifer (Cologne, Germany), Daniel Schafer (Cologne, Germany) and Ian Johnston (Rosrath, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are chimeric antigen receptors (CARs) that include a) an antigen binding domain specific for an antigen, b) a spacer, c) a transmembrane domain, and d) an intracellular signaling domain, wherein the spacer consists of 1, 2 or 3 C2-set Ig-like domain(s) e.g., C2-set Ig-like domains of the sialic acid...