US Patent Issued to MICROSOFT TECHNOLOGY LICENSING on Aug. 26 for "Regulation of polymerase using cofactor oxidation states" (Washington Inventor)

ALEXANDRIA, Va., Aug. 26 -- United States Patent no. 12,398,412, issued on Aug. 26, was assigned to MICROSOFT TECHNOLOGY LICENSING LLC (Redmond, Wash.).

"Regulation of polymerase using cofactor oxidation states" was invented by Bichlien Hoang Nguyen (Seattle).

According to the abstract* released by the U.S. Patent & Trademark Office: "Polynucleotide synthesis performed with a template independent polymerase such as terminal deoxynucleotidyl transferase (TdT) is regulated by controlling the oxidation state of a metal cofactor. The oxidation state of the metal cofactor is changed to +2, thus activating the polymerase, by applying a voltage with electrodes or by introducing a chemical redox reagent. Addressable polynucleotide synthesis creat...