US Patent Issued to Merck Sharp & Dohme on Sept. 30 for "Hydroxypyrrolidine-substituted arylsulfonamide compounds with selective activity in voltage-gated sodium channels" (Chinese, American Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,427,159, issued on Sept. 30, was assigned to Merck Sharp & Dohme LLC (Rahway, N.J.).

"Hydroxypyrrolidine-substituted arylsulfonamide compounds with selective activity in voltage-gated sodium channels" was invented by Anthony J. Roecker (Harleysville, Pa.), Mark E. Layton (Harleysville, Pa.), Deping Wang (Furlong, Pa.), Xiu Wang (Shanghai) and Xuanjia Peng (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are compounds of Formula A, or a salt thereof: Wherein "A1", R1, R2, R3, R6, and R7 are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described ar...