ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,427,187, issued on Sept. 30, was assigned to Merck Sharp & Dohme LLC (Rahway, N.J.).
"Glucose-responsive insulin conjugates" was invented by Danqing Feng (Green Brook, N.J.), Songnian Lin (Holmdel, N.J.), Dmitri A. Pissarnitski (Scotch Plains, N.J.), Brenda Pipik (Edison, N.J.), Lin Yan (East Brunswick, N.J.) and Yuping Zhu (Basking Ridge, N.J.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Glucose-responsive insulin conjugates that contain one or more linear oligomer sugar cluster are provided. Such insulin conjugates that may display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a sacc...