US Patent Issued to Merck Sharp & Dohme on Nov. 11 for "Small molecule inhibitors of KRAS proteins" (Japanese, British, American Inventors)

ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,466,840, issued on Nov. 11, was assigned to Merck Sharp & Dohme LLC (Rahway, N.J.).

"Small molecule inhibitors of KRAS proteins" was invented by Shuhei Kawamura (Cambridge, Mass.), Yu Kobayakawa (Ibaraki, Japan), Tsuyoshi Oshima (Ibaraki, Japan), Takao Uno (Ibaraki, Japan) and Patrick Schopf (London).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compounds of Formulae (I)-(VII) or their pharmaceutically acceptable salts can inhibit the G12C, G12D, G12V, and/or G13D mutants of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions...