US Patent Issued to Merck Sharp & Dohme on March 25 for "Pyrimidone derivatives as selective cytotoxic agents against HIV infected cells" (Pennsylvania Inventors)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,329, issued on March 25, was assigned to Merck Sharp & Dohme LLC (Rahway, N.J.).

"Pyrimidone derivatives as selective cytotoxic agents against HIV infected cells" was invented by Antonella Converso (Elkins Park, Pa.) and Cheng Wang (Fort Washington, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related ...