US Patent Issued to Merck Sharp & Dohme on Jan. 27 for "Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors" (Pennsylvania Inventors)

ALEXANDRIA, Va., Jan. 28 -- United States Patent no. 12,534,458, issued on Jan. 27, was assigned to Merck Sharp & Dohme LLC (Rahway, N.J.).

"Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors" was invented by Ian M. Bell (Harleysville, Pa.), Brendan M. Crowley (Collegeville, Pa.) and Philippe Nantermet (Lansdale, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to compounds of formula (I) that are useful as modulators of Alpha7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's di...