US Patent Issued to Merck Patent on Dec. 23 for "Reuse of intein-bound resins for protein purification" (German Inventors)

ALEXANDRIA, Va., Dec. 23 -- United States Patent no. 12,503,488, issued on Dec. 23, was assigned to Merck Patent GmbH (Darmstadt, Germany).

"Reuse of intein-bound resins for protein purification" was invented by Oliver Rammo (Darmstadt, Germany) and Romas Skudas (Darmstadt, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to methods of protein purification by attaching an intein-C fragment to a target protein, passing a sample containing the intein-C tagged protein over a chromatographic resin carrying an intein-N fragment so as to create an intein-N intein-C complex, releasing the target protein from the intein-C fragment, and regenerating the column under conditions tha...