ALEXANDRIA, Va., July 30 -- United States Patent no. 12,371,494, issued on July 29, was assigned to MEDICOVESTOR INC. (Wilmington, Del.).
"Methods of manufacturing dimeric antibodies" was invented by Seah Lim (Wilmington, Del.).
According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure relates to dimeric immunotherapeutics that comprise two IgGs that are crosslinked with a disulfide bond. The two IgGs may be chimeras of two different heavy chains, in which one heavy chain includes a cysteine mutation that forms the disulfide bond, and the other heavy chain lacks the cysteine mutation. The presence of a cysteine mutation in only one of the heavy chains of an IgG avoids two disulfide bonds between the two I...