US Patent Issued to Massachusetts Institute of Technology on Nov. 18 for "Splicing-dependent transcriptional gene silencing or activation" (Massachusetts Inventors)

ALEXANDRIA, Va., Nov. 18 -- United States Patent no. 12,473,549, issued on Nov. 18, was assigned to Massachusetts Institute of Technology (Cambridge, Mass.).

"Splicing-dependent transcriptional gene silencing or activation" was invented by Christopher B. Burge (Belmont, Mass.) and Ana Fiszbein (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are methods for inhibiting or activating the transcription of a gene of interest, or inhibiting or activating the transcription of specific mRNA isoforms of a gene by using antisense oligonucleotides and/or small molecules. Also described herein are methods for activating transcription from a promoter and increasing overall gene expressio...