US Patent Issued to Massachusetts Institute of Technology on May 27 for "MicroRNA-based logic gates and uses thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., June 17 -- United States Patent no. 12,312,583, issued on May 27, was assigned to Massachusetts Institute of Technology (Cambridge, Mass.).

"MicroRNA-based logic gates and uses thereof" was invented by Ron Weiss (Newton, Mass.) and Giulio Alighieri (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure, at least in part, relates to a miRNA based logic gate that comprises an engineered RNA carrier that comprises an nuclear export signal, a target site for a first miRNA and a pre-miRNA sequence for a second miRNA. Also provided by the disclosure are recombinant viruses (e.g., recombinant adeno-associated viruses (rAAV)) for delivery of the miRNA based logic gat...