US Patent Issued to Massachusetts Institute of Technology on June 17 for "Phosphorylation-based miRNA sensor" (Massachusetts Inventors)

ALEXANDRIA, Va., June 19 -- United States Patent no. 12,331,298, issued on June 17, was assigned to Massachusetts Institute of Technology (Cambridge, Mass.).

"Phosphorylation-based miRNA sensor" was invented by Ron Weiss (Newton, Mass.), Ross D. Jones (Cambridge, Mass.) and Jin Huh (Watertown, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. The cell state classifiers of the present disclosure utilize phosphorylation state of a transcription factor to control classifier output. Kinases and phosphatase pairs that function in phosphorylating or dephosphorylating the transcription factor are integra...